Adaptive Circuit Targeting (ACT) DBS combines the “when to stimulate” approach of adaptive DBS with the “where to stimulate” principle of connectomic DBS. By decoding symptoms in real time and targeting the right brain circuits, it promises more personalized and effective treatment for conditions like Parkinson’s, dystonia, and OCD. While challenges remain—such as improved sensing, circuit mapping, and smarter hardware—the technology is advancing quickly toward truly intellig

This article explores two fascinating frontiers in neuroscience: A groundbreaking ALS study where scientists reactivated developmental genes (ISL1 and LHX3) to “rejuvenate” motor neurons, reducing stress and delaying disease progression in mice. And a new framework for understanding near-death experiences (NDEs), showing how neurobiology, evolution, and psychology combine to create profound, life-altering experiences at the edge of consciousness.

A new Harvard study reveals that the brains of Alzheimer's patients are deficient in lithium because the element gets trapped by amyloid plaques. In mouse models, a low dose of a special form called lithium orotate bypassed these traps, successfully reducing plaques and inflammation while restoring memory. This research suggests that addressing this lithium deficiency could be a promising new approach to treating Alzheimer's disease.