Narcissistic Personality Disorder (NPD) is a mental health condition in which people have an exaggerated sense of self-importance. They constantly seek admiration and attention from others but lack the ability to understand or care about others’ feelings. This disorder affects about 1–2% of the population, with men being diagnosed more often than women. NPD usually emerges during adolescence or early adulthood.

Different anesthetics, though acting via distinct pathways, converge on a shared effect: re-aligning brain oscillations. Both ketamine and dexmedetomidine increased low-frequency synchronization across hemispheres while fragmenting within-hemisphere communication. These dose-dependent phase shifts may represent a common mechanism for loss of consciousness and offer potential biomarkers for anesthesia depth.

Adaptive Circuit Targeting (ACT) DBS combines the “when to stimulate” approach of adaptive DBS with the “where to stimulate” principle of connectomic DBS. By decoding symptoms in real time and targeting the right brain circuits, it promises more personalized and effective treatment for conditions like Parkinson’s, dystonia, and OCD. While challenges remain—such as improved sensing, circuit mapping, and smarter hardware—the technology is advancing quickly toward truly intellig

This article explores the NEPTUNE model, a neuroscience framework that explains near-death experiences (NDEs). Instead of mystical visions, NDEs may emerge from brain crisis responses: oxygen loss, hyperactive neural circuits, and a powerful surge of neurotransmitters. Combined with evolutionary defense strategies and psychological interpretation, these processes create the vivid, life-changing experiences survivors often describe as “more real than real life.”

This article explores two fascinating frontiers in neuroscience: A groundbreaking ALS study where scientists reactivated developmental genes (ISL1 and LHX3) to “rejuvenate” motor neurons, reducing stress and delaying disease progression in mice. And a new framework for understanding near-death experiences (NDEs), showing how neurobiology, evolution, and psychology combine to create profound, life-altering experiences at the edge of consciousness.

A new Harvard study reveals that the brains of Alzheimer's patients are deficient in lithium because the element gets trapped by amyloid plaques. In mouse models, a low dose of a special form called lithium orotate bypassed these traps, successfully reducing plaques and inflammation while restoring memory. This research suggests that addressing this lithium deficiency could be a promising new approach to treating Alzheimer's disease.